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Question:

How do the penalties for alcohol-related DWI and drug-related DWI compare?

A There is no difference in penalties.
Explaination

Under Louisiana law, whether you were driving under the influence of alcohol, illegal drugs, prescription medications, or even over-the-counter medications, the penalties are the same. [Drugs, Chapter 9: Driving Offenses, Littering, Revocation of Your License, Louisiana Class D & E Driver's Guide]